Formalin-fixed, paraffin-embedded tissue blocks of enrolled cases were used to make three-micrometer-thick sections. His CT and MRI scans found only thickness of the oropharyngeal wall and epiglottal folds, and a superficial biopsy revealed only inflammation. Diffuse large B-cell lymphoma and mantle cell lymphoma of the ocular adnexal region, and lymphoma of the lacrimal gland: an investigation of clinical and histopathological features. https://doi.org/10.4103/0973-1482.136024. PTCL, NOS occurring at the base of the tongue are rare. Russo S, Lo Re G, Galia M, Reginelli A, Lo Greco V, D'Agostino T, La Tona G, Coppolino F, Grassi R, Midiri M, Lagalla R. Radiol Med. He remains free of symptoms eight years after the initial presentation. It is caused by an abnormal expansion of the interfollicular zones but is confined within the lymph node capsule. Shiozawa E, Takimoto M, Makino R, Adachi D, Saito B, Yamochi-Onizuka T, Yamochi T, Shimozuma J, Maeda T, Kohno Y, Kawakami K, Nakamaki T, Tomoyasu S, et al. a. CT showed a well-bordered cystic mass. Article HHS Vulnerability Disclosure, Help 2013;119:18327. b. H&E showed immunoblastic large cells with an obvious nucleolus (200 x). Mitosis could be observed easily. 4, pp. Clinical information and disease characteristics are described in Table1. The authors declare that they have no competing interests. The DLBCL, NOS cases were further divided into GC and NGC B cell like subtypes based on immunohistochemical expression of CD10, Bcl-6 and Mum1 [11]. e. HPV DNA ISH showed brown punctate dots in the tumour cell nucleus or cytoplasm (400x).f. MCLs in the tongue base are even rarer. This entity was first described in 1973 by Adkins. Sun J, Zhang J, Ling Q, Luo Y, Wu S, Liang Z, Zhong D, Zeng X. 2023 BioMed Central Ltd unless otherwise stated. Reference Sands and Tewfik 1 The aetiology is poorly understood, . Squamous cell hyperplasia is characterized by increased cell numbers, which usually results in increased thickness of the squamous epithelium. On this Wikipedia the language links are at the top of the page across from the article title. This patient had a partial response to chemotherapy and died 63months after diagnosis. Mohd Ridah LJ, A Talib N, Muhammad N, Hussain FA, Zainuddin N. p16 Tumor Suppressor Gene Methylation in Diffuse Large B Cell Lymphoma: A Study of 88 Cases at Two Hospitals in the East Coast of Malaysia. Federal government websites often end in .gov or .mil. Lee ES, Kim LH, Abdullah WA, Peh SC. Only one widely disseminated case has been referenced, which involved cervical nodes, major salivary glands, orbits, and mediastinum [4]. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot . Imaging showed a well-bordered cystic mass (2cm in diameter) at the right base of the tongue that extended into the pharynx, and so a biopsy was performed. 2, pp. Imaging and pathological findings of MCL (case 2). Epub 2018 Jun 25. showed that 74% of DLBCL cases have P16 methylation and a relatively old age [32]. Vose JM. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. ZL, BW, XR and YC reviewed all the cases together. Non-Hodgkins lymphoma (NHL) primarily derived from the base of the tongue, is rare. One of the DLBCL cases was positive for HPV DNA and diffusely expressed P16 protein. We not only report on the general clinicopathological features, including age, gender, tumour location, histological subtypes, grading and staging, but also provide important information related to prognosis and treatment. DNA was extracted from paraffin-embedded tissue using standard DNA isolation kits (QIAGEN, 56404). Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. 2007;29:627. Rinsho Ketsueki. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, et al. Open tracheotomy was performed on POD 3 due to the absence of a leak, and biopsies were again performed, which ultimately revealed the equivalent benign pathologic findings. DLBCL with high risk factors and MCL may have unfavourable outcomes. https://doi.org/10.1186/s13000-020-00936-w, DOI: https://doi.org/10.1186/s13000-020-00936-w. https://www.linkedin.com/showcase/4000114/. 1, pp. 1998;112:9914. This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. Google Scholar. Mucosa-associated lymphoid tissue lymphoma of the lingual tonsil. Except in one case of four, all of our patients were alive through follow-up. They are covered by stratified squamous nonkeratinized epithelium and contain deep crypts and mucosal glands. official website and that any information you provide is encrypted Ann Oncol. Immunohistochemistry was negative for lymphoma. Other features include presence of white spaces and lymphocytes (large cells) within sinuses. [1] The growth is termed hyperplasia which may result in enlargement of various tissue including an organ, or cause a cutaneous lesion. https://doi.org/10.1111/aos.12189. This site needs JavaScript to work properly. Sirsath NT, Lakshmaiah KC, Das U, Lokanatha D, Chennagiri SP, Ramarao C. Primary extranodal non-Hodgkin's lymphoma of oral cavity--a single Centre retrospective study. Takahashi H, Fujita S, Okabe H, Tsuda N, Tezuka F. Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity. b. The follicles are cytologically polymorphous, are often polarized, and vary in size and shape. Spontaneous regression has also been reported. This site needs JavaScript to work properly. official website and that any information you provide is encrypted But when areas of focal nodular lymphoid hyperplasiawhich are well-known to occur in other areas of the bodyoccur in the mouth, they create a perplexing dilemma for dental professionals. Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. Never disregard or delay professional medical advice in person because of anything on HealthTap. Pathology may also show indistinct germinal centres leading to erroneous diagnosis of follicular lymphoma [3]. Neville BW, Damm DD, Allen CM, Chi AC. 2005;29:128493. Before What does prominent lymphoid tissue at base of tongue on an MRI report mean. [Diagnostics of laryngopharyngeal form of gastroesophageal reflux disease for adults (Lithuanian clinical practice guidelines)]. Before The number of cases in the present study was low, so further studies will be needed to better understand the relationship between HPV infection and lymphoma of the base of the tongue. a. MRI showed a mass in the base of the tongue sticking to the pharyngeal cavity and making it obviously narrow. 2002;15:4205. Surgical debulking/excision is the treatment of choice. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. [7]. Hi, my biopsy says reactive lymphoid hyperplasia, does it means it is benign? Blood. Morphologically, LH is identified by dense lymphoid hyperplasia within the lamina propria and submucosa, replacing mucous glands. The complaints due to severe HBT were noisy respiration, hoarseness, throat clearing, dry cough, globus pharyngeus, and nasal voice. These tonsils contain B and T lymphocytes which get activated when harmful bacteria and viruses come in contact with tonsils. In addition, patients may notice irregularities on their own, thereby bringing the appearance to the attention of their dentists or hygienists. [citation needed], It is one common source of appendicitis, as it may cause an obstruction of the appendiceal lumen, resulting in the subsequent filling of the appendix with mucus, causing it to distend and internal pressure to increase. 2010;47:846. What is the treatment for reactive lymphoid hyperplasia? 1998;18:38792. Radiol Clin North Am. Acta Ophthalmol. Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status. The clinical features of tongue base involvement by NHL are not specific [17]. Cookies policy. Primary diffuse large B-cell lymphoma of the ovary is of a germinal Centre B-cell-like phenotype. b. H&E showed moderate to large cells with distorted nuclear contours (200 x). Head Neck. A woman in her fourth decade was admitted with a one-month history of pharyngeal foreign body sensation. 2005;34:3915. Eur Arch Otorhinolaryngol. By using our website, you consent to our use of cookies. The study utilized immunochemistry, in situ hybridization (ISH), and gene rearrangement to confirm the disease and and performed a clinical follow up for each case. e. Tumour cells were positive for Cyclin D1 (200x). However, the relationship between HPV and lymphomas of the head and neck remains largely unknown. It is caused by an abnormal proliferation of secondary follicles and occurs principally in the cortex without broaching the lymph node capsule. AJR Am J Roentgenol. [2], A lymph node is small, capsulated lymphoid organ that is present along the lymphatic system. PubMed Central With proper therapy, even late stage tongue base lymphomas can be suppressed and remain in remission. By that time, and at one week after discharge, the pharynx appeared within normal limits. Authors M Gromet , M J Homer , B L Carter PMID: 7111732 DOI: 10.1148/radiology.144.4.7111732 No abstract available Publication types Case Reports MeSH terms Adult Barium Sulfate Deglutition Diagnosis, Differential Female Video chat with a U.S. board-certified doctor 24/7 in a minute. CAS Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. 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